2021-05-11-rr-all-annota-ASD-CHD

ASD

1	readRDS("/storage11_7T/fuy/TADA-A/cell_WES/DNM/results/0511-all-rr.rds")

A data.table: 23 × 4
separate_logRR	upper_bound	lower_bound	annota
<dbl>	<dbl>	<dbl>	<chr>
-1.000000	1.2069758	-3.2069758	miRNA.SNP.UTR pval < 0.05
-1.000000	0.1926188	-2.1926188	spidex: no nonsyn & stop gain & loss
-0.342154	2.6829561	-3.3672642	RADAR: top5% variants in the post-transcriptional regulome of RBP
-1.000000	2.8204961	-4.8204960	RADAR: top1%
-1.000000	3.5018739	-5.5018738	all RBP biding regions & RADAR top1%
1.599488	3.0837531	0.1152234	hnRNPL binding regions
1.897444	2.1033770	1.6915119	coding constraint >= 90
1.844203	2.2785397	1.4098657	dbSNP.RBP-Var: likely to affcted RNA-bind, RNA 2nd structure
1.312018	1.6459882	0.9780486	RNA modifications, including m6a, m1A, m5C, and etc.(filter_low_RMVar_hb)
2.483918	2.9038365	2.0639991	deepsea: mix ago_adult_brain.BA4 & ago_adult_brain.Cingulate.gyrus
2.592861	3.0063684	2.1793531	deepsea: mix elavl_Adult_brain.all_human_samples & elavl_Adult_brain.BA9_Alzheimer & elavl_Adult_brain.BA9
1.621601	1.8358553	1.4073458	1<= mpc score < 2
2.321405	2.5479509	2.0948598	mpc score >= 2
2.600493	2.8280700	2.3729150	interaction-disrupting: mutations annotated as interface residues and probably damaging by PolyPhen-2
1.757185	1.8924045	1.6219658	pathogenic missense: primateAI_MVP_mix
1.773391	1.9670277	1.5797548	spidex_lower10pct
1.997280	3.6649529	0.3296074	spliceAI accept gain >= 0.05
2.800307	3.4769404	2.1236739	spliceAI donnor gain >= 0.05
2.081598	2.5579298	1.6052671	ptv in [0,0.5)
2.209710	2.9645287	1.4548916	ptv in [0.5,0.995)
3.493791	3.7594861	3.2280951	ptv in [0.995,1)
-1.000000	-12.3062344	10.3062344	spliceAI accept loss >= 0.05
0.365112	-0.5284987	1.2587227	spliceAI donor loss >= 0.05

CHD

1	readRDS("/storage11_7T/fuy/TADA-A/CHD/rds/0512_all_annota_rr.rds")

A data.frame: 24 × 5
logRR	lower_bound	upper_bound	idx	annota
<dbl>	<dbl>	<dbl>	<dbl>	<chr>
-1.000000	3.298834	-5.29883368	1	miRNA.SNP.UTR pval < 0.05
-1.000000	27.517077	-29.51707721	2	RNAedit RBP-Var: likely to affected RNA-bind, RNA 2nd structure
1.687606	2.192012	1.18320074	3	coding constraint >= 90
-1.000000	7.393399	-9.39339857	4	RNA modifications, including m6a, m1A, m5C, and etc.(filter_low_RMVar_hb)
1.814882	2.339178	1.29058489	5	RADAR: top5% variants in the post-transcriptional regulome of RBP
2.194627	2.734925	1.65432873	6	dbSNP.RBP-Var: likely to affcted RNA-bind, RNA 2nd structure
-1.000000	3.287827	-5.28782647	7	RBP-VarDB
-1.000000	4.715246	-6.71524547	8	ribosnitch
-1.000000	12.532978	-14.53297803	9	CLIPdb
2.430548	3.074458	1.78663714	10	deepsea: mix ago_adult_brain.BA4 & ago_adult_brain.Cingulate.gyrus
1.738795	3.155253	0.32233776	11	deepsea: mix elavl_Adult_brain.all_human_samples & elavl_Adult_brain.BA9_Alzheimer & elavl_Adult_brain.BA9
1.813293	2.139593	1.48699171	12	1<= mpc score < 2
2.058641	2.554155	1.56312683	13	mpc score >= 2
2.307627	2.803729	1.81152465	14	interaction-disrupting: mutations annotated as interface residues and probably damaging by PolyPhen-2
2.035133	2.225165	1.84509985	15	pathogenic missense: primateAI_MVP_mix
2.030793	2.296126	1.76545964	16	spidex_lower10pct
2.944004	4.195226	1.69278194	17	spliceAI accept gain >= 0.05
2.472156	3.889113	1.05519861	18	spliceAI donnor gain >= 0.05
-1.000000	17.383819	-19.38381850	19	spliceAI accept loss >= 0.05
2.156331	4.376120	-0.06345714	20	spliceAI donor loss >= 0.05
2.283768	2.944003	1.62353425	21	ptv in [0,0.5)
3.039657	3.769662	2.30965246	22	ptv in [0.5,995)
3.701728	4.160876	3.24258001	23	ptv in [0.995,1)
-1.000000	6.713247	-8.71324678	24	hnRNPL RNA-binding