2021-10-01-tadaA-report
simulationsample size = 20000
num of genes = 5000
10 annotations, with logRR = c(4,3,2,1.5,1,-8,-6,-5,-3,-1)
prior=0.05
100 rounds of simulation
stati ...
2021-09-06-tadaA-report
Statistics of previous simulated parameters
N=6000, logRR=3,2,1, prior=0.05
100 rounds of simulation
1readRDS("/storage11_7T/fuy/TADA-A/cell_WES ...
2021-08-26-all-RR
Union of Deepsea catagories significant in S3 or S4.
S3: Results of RBP dysregulation effect on psychiatric disorder risk
ASD, SCZ, MDD, BD, ADHD
S4 ...
2021-08-10-tadaA-report
Check RR, prior, and FDR by simulationparameters: 3 annotations (Lof: ptv > 0.995, union of spidex_low3 and spliceai, without ptv, mpc>2) , log- ...
2021-08-10-ASD-CHD-res-comparison
ASD12readRDS("/storage11_7T/fuy/TADA-A/cell_WES/DNM/2021-08-11_selected14_riskG_num_compare.rds")readRDS("/storage11_7T/fuy/TADA-A/cell ...
2021-08-10-nonfs-rate-fs-gama-report
inframe rate123456789101112131415161718192021222324252627282930313233343536# all4 = fread("/storage11_7T/fuy/TADA-A/cell_WES/DNM/affected/indel/1 ...
2021-06-15-ASD-fs-rate-gama-report
num of nonframeshift mutations (inframe_deletion, inframe_insertion) from the affected
siblings中nonfs数量太少（35个），glm得到的结果不显著，因此用affected中的nonfs
123456li ...
2021-06-01-CHD-selected13-all-rr-info
joint estimation1readRDS("/storage11_7T/fuy/TADA-A/CHD/rds/2021-05-28_selected13_CHD_sf_allinfo_rr.rds")
A data.frame: 13 × 7
annota ...
2021-05-25-tadaA-report
目前进展及分析
详见1,2
下一步计划
100 rounds simulation (尚未完全跑完)
完成CHD部分
挑选candidate genes
ASDsimulationparameters:
3 annotations (Lof: ptv > 0.995, union of ...
2021-05-24-nonfs-rate-fs-gama-Copy1
12345678910111213141516171819library(data.table)options(digits=22)N = 2179 ### sample sizedf = read.table("/storage11_7T/fuy/TADA-A/cell_WES/DNM/ ...